https://covariants.org/_next/static/chunks/5891.f947fac93e283d72.js

1"use strict";(self.webpackChunk_N_E=self.webpackChunk_N_E||[]).push([[5891],{85891:(n,e,r)=>{r.r(e),r.d(e,{default:()=>o});var s=r(67684),x=r(62701),i=r(37876),m=r(91668),t=r(33086);function j(n){var e=(0,s._)({br:"br",em:"em",h3:"h3",p:"p"},(0,m.R)(),n.components),r=e.AaMut,x=e.MdxContent,j=e.Mut,o=e.VarOrLin,c=e.VarOrLinText,p=e.Who;return r||a("AaMut",!0),x||a("MdxContent",!0),j||a("Mut",!0),o||a("VarOrLin",!0),c||a("VarOrLinText",!0),p||a("Who",!0),(0,i.jsxs)(i.Fragment,{children:[(0,i.jsx)(x,{filepath:"clusters/VoCHeader.mdx"}),"\n",(0,i.jsx)(e.h3,{id:"",children:(0,i.jsx)(c,{name:"21L (Omicron)"})}),"\n",(0,i.jsxs)(e.p,{children:["也称为",(0,i.jsx)(o,{name:"21L (Omicron)",invert:!0}),"和",(0,i.jsx)(p,{name:"Omicron"})]}),"\n",(0,i.jsx)(x,{filepath:"clusters/OmicronHeader.mdx"}),"\n",(0,i.jsxs)(e.p,{children:[(0,i.jsx)(o,{name:"21L (Omicron)"}),"和",(0,i.jsx)(o,{name:"21K (Omicron)",prefix:""})," 共享38个核苷酸和氨基酸突变， 但 ",(0,i.jsx)(o,{name:"21L (Omicron)",prefix:""}),"有额外的27个， 而 ",(0,i.jsx)(o,{name:"21K (Omicron)",prefix:""}),"有额外的20个。"]}),"\n",(0,i.jsxs)(e.p,{children:["只看刺突的话，两者都有 21 个氨基酸突变，其中",(0,i.jsx)(o,{name:"21K (Omicron)",prefix:""}),"携带额外的 12 个独特的氨基酸突变，而 ",(0,i.jsx)(o,{name:"21L (Omicron)",prefix:""})," 携带额外的 6个（加上缺失/突变 - 见下文）。值得注意的是，",(0,i.jsx)(o,{name:"21L (Omicron)",prefix:""})," 缺少",(0,i.jsx)(r,{mut:"S:H69-"}),"和",(0,i.jsx)(r,{mut:"S:V70-"})," 处的缺失（见",(0,i.jsx)(j,{name:"S:H69-"}),"），这就是“S 基因丢失”或 SGTF 在 TaqPath PCR 测试中用于追踪 ",(0,i.jsx)(o,{name:"21K (Omicron)",prefix:""})," 的情况。"]}),"\n",(0,i.jsxs)(e.p,{children:[(0,i.jsx)(o,{name:"21L (Omicron)",prefix:""}),"中的6个额外的刺突突变是：",(0,i.jsx)(r,{mut:"S:T19I"}),"、",(0,i.jsx)(r,{mut:"S:V213G"}),"、",(0,i.jsx)(r,{mut:"S:S371F"}),"、",(0,i.jsx)(r,{mut:"S:T376A"}),"、",(0,i.jsx)(r,{mut:"S:D405N"}),"和",(0,i.jsx)(r,{mut:"S:R408S"}),"。",(0,i.jsx)(e.br,{}),"\n","最重要的是，从位置 21633-21641 有一个 9 个核苷酸的缺失，导致缺失和突变 ",(0,i.jsx)(r,{mut:"S:L24-"}),"、",(0,i.jsx)(r,{mut:"S:P25-"}),"、",(0,i.jsx)(r,{mut:"S:P26-"}),"和 ",(0,i.jsx)(r,{mut:"S:A27S"})," (与其他缺失/突变一样，有时也将其报告为",(0,i.jsx)(r,{mut:"S:L24S"}),"，然后是 3 处缺失 —— 产生的蛋白质是相同的）."]}),"\n",(0,i.jsxs)(e.p,{children:[(0,i.jsx)(r,{mut:"ORF1a:L3201F"})," 在 ",(0,i.jsx)(o,{name:"21L (Omicron)",prefix:""}),"中多次出现，但怀疑这种变体起源的南非，它最常见的是野生型 (L)。在南非以外，",(0,i.jsx)(r,{mut:"ORF1a:L3201F"})," 突变更为常见。因此，分支",(0,i.jsx)(o,{name:"21L (Omicron)",prefix:""}),"可能有也可能没有",(0,i.jsx)(r,{mut:"ORF1a:L3201F"}),"，取决于它们是否来自携带此突变的",(0,i.jsx)(o,{name:"21L (Omicron)",prefix:""})," 的一部分。值得注意的是，被认为起源于南非的",(0,i.jsx)(o,{name:"22A (Omicron)",prefix:""}),"和",(0,i.jsx)(o,{name:"22B (Omicron)",prefix:""}),"_并没有_这个突变，然而被认为起源于北美的 ",(0,i.jsx)(o,{name:"22C (Omicron)"}),"却有这个突变。"]}),"\n",(0,i.jsxs)("i",{children:["感谢Andrew Rambaut的",(0,i.jsx)(t.e,{href:"https://github.com/cov-lineages/pango-designation/issues/361",children:"这篇文章"})," 帮助识别突变"]}),"\n",(0,i.jsx)(e.p,{children:(0,i.jsx)(e.em,{children:"如果可以，请提供有关此变体的更多信息的链接来帮助我们！"})})]})}function o(){var n=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{},e=(0,s._)({},(0,m.R)(),n.components).wrapper;return e?(0,i.jsx)(e,(0,x._)((0,s._)({},n),{children:(0,i.jsx)(j,(0,s._)({},n))})):j(n)}function a(n,e){throw Error("Expected "+(e?"component":"object")+" `"+n+"` to be defined: you likely forgot to import, pass, or provide it.")}r(80727)}}]);
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