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The milestone highlights growing industry demand for configurable technology and enablement services to simplify the operational complexity of modern clinical trial designs while speeding up study launch timelines.</p><p>Building on the <a target="_blank" rel="noopener" href="https://www.threadresearch.com/press-releases/thread-launches-new-adaptive-trials-solution">launch of its Adaptive Trials Solution</a> earlier this year, THREAD's configurable platform enables sponsors to operationalize basket, umbrella, multi-arm, and other adaptive study designs within a single protocol. Since the feature's release, sponsors have leveraged the platform to rapidly configure complex participant pathways, cohort management, protocol adaptations, and study governance without custom development on global Phase Ib â IV clinical trials and registries.</p><p>The adoption aligns with recent regulations that continue to encourage more efficient approaches to evidence generation. <a target="_blank" rel="noopener" href="https://www.fda.gov/industry/fda-actions-accelerate-and-modernize-early-and-late-stage-clinical-development">Recent FDA initiatives</a> supporting the use of well-designed single pivotal trials, alongside expanded guidance for adaptive clinical trial designs, are creating new opportunities for sponsors to accelerate development while maintaining rigorous scientific standards. Adaptive trials allow sponsors to make pre-specified modifications based on interim data that help optimize patient enrollment, allocate resources more effectively, and potentially reach pivotal endpoints with greater eff
1iciency when appropriately planned.</p><p>THREAD's Adaptive Trials Solution provides research teams with configurable workflows that support:</p><ul><li>Dynamic participant pathways across multiple cohorts and treatment arms</li><li>Rapid implementation of protocol adaptations</li><li>Role-based governance for participant transitions</li><li>Automated visit and task management that maintains a seamless participant experience</li><li>A single study configuration capable of supporting evolving trial designs</li></ul><p>"We're seeing a meaningful shift in how sponsors think about pivotal trial design and the volume of adaptive study designs we are receiving," said John Reites, Co-founder and CEO of THREAD. "We are grateful for the opportunity to support our clients with these new adaptive clinical trials to demonstrate how our platform and scientific consulting deliver the results they need in a partner.â</p><p>To learn more about THREAD's Adaptive Trials Solution or schedule a demonstration, visit <a target="_blank" rel="noopener" href="https://www.threadresearch.com/adaptive-trial">https://www.threadresearch.com/adaptive-trial</a></p><p></p><p>##</p><p></p><p><strong>About THREAD</strong></p><p>THREADâs® purpose is to leverage its clinical research platform to enable studies for everyone, everywhere. Through its uniquely combined research technology and scientific consulting services, THREAD helps life science organizations to design, operate, and scale next-generation research studies and electronic clinical outcome assessments (eCOA) programs for participants, sites, and study teams. Through its comprehensive platform and scientific expertise, THREAD empowers studies to be accessible, efficient, and human-centered.</p><p>THREAD has been recognized as a leader by Everest Group in its Decentralized Clinical Trial Product PEAK Matrix® Assessments from 2021 through 2023, is positioned in the Leaders Category of the 2022 IDC MarketScape for R&D Decentralized Clinical Trial Technology Solutions Vendor Assessment, and is named a Major Contender in Everest Groupâs Life Sciences eCOA Products PEAK Matrix® Assessment 2025.</p><p></p><p>Media Contact</p><p>Les Yates<br/>THREAD<br/>[email protected]</p></div><div class="mx-auto max-w-4xl pb-4"><section class="rounded-3xl border border-border/60 bg-muted/35 px-6 py-8 shadow-sm sm:px-10 sm:py-12"><div class="mx-auto flex max-w-3xl flex-col items-center text-center"><img alt="THREAD logo" loading="lazy" width="328" height="66" decoding="async" data-nimg="1" class="w-36 sm:w-44" style="color:transparent" srcSet="/_next/image?url=%2F_next%2Fstatic%2Fmedia%2Fthread-logo.f98ea859.png&w=384&q=75 1x, /_next/image?url=%2F_next%2Fstatic%2Fmedia%2Fthread-logo.f98ea859.png&w=750&q=75 2x" src="/_next/image?url=%2F_next%2Fstatic%2Fmedia%2Fthread-logo.f98ea859.png&w=750&q=75"/><div class="prose dark:prose-invert mt-6 max-w-2xl prose-a:no-underline prose-a:text-brand prose-p:text-balance prose-p:text-muted-foreground prose-strong:text-foreground hover:prose-a:brightness-110 [&_p]:my-0 [&_p+p]:mt-4 sm:prose-lg"><p><strong>THREAD®</strong> provides a fully configurable clinical research platform to enable studies for everyone, everywhere. Through its industry-leading technology and scientific expertise, we empower studies to be more accessible, efficient, and patient-centered.</p></div><div class="mt-8 flex w-full flex-col items-center justify-center gap-4 sm:flex-row"><a class="antialiased no-underline inline-flex items-center justify-center whitespace-nowrap rounded-md shadow-sm focus:outline-none focus:ring-2 focus:ring-teal-500 focus:ring-offset-2 min-w-[240px] border border-border/60 shadow-[0_10px_30px_-14px_rgba(15,23,42,0.4)] bg-white text-black text-lg px-8 py-3" tabindex="0" style="font-weight:575;font-stretch:133%;background-image:none;color:#0997BE" href="/request-a-demo">Request a Quick Demo</a><a class="antialiased no-underline inline-flex items-center justify-center whitespace-nowrap rounded-md shadow-sm focus:outline-none focus:ring-2 focus:ring-teal-500 focus:ring-offset-2 min-w-[240px] border border-border/60 shadow-[0_10px_30px_-14px_rgba(15,23,42,0.4)] bg-white text-black text-lg px-8 py-3" tabindex="0" style="font-weight:575;font-stretch:133%;background-image:none;color:#0997BE" href="/#platform-video">Watch Our Platform Video</a></div></div></section></div></div></div></div><footer class="bg-[#f8fbfc]" aria-labelledby="footer-heading"><h2 id="footer-heading" class="sr-only">THREAD</h2><div class="mx-auto max-w-screen-2xl px-4 py-8 sm:px-6 lg:px-8 lg:pt-24"><div class="xl:grid xl:grid-cols-[minmax(0,1.2fr)_minmax(0,1fr)] xl:gap-16"><div class="flex flex-col gap-12 md:flex-row md:items-center xl:items-start xl:flex-col"><div class="space-y-4"><svg class="max-w-full" width="140" height="42" viewBox="0 0 1791 359" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M555.48 1V358.38H533.58V201.09H382.27V179.19H533.58V1H555.48ZM320.83 1H0V21.9H132.4V358.37H154.3V21.9H320.55V358.37H342.45V202.87V180.17V1H320.83ZM661.41 22.9H740.64C756.81 23.36 772.74 26.82 787.64 33.11C816.77 45.88 832.09 68.86 832.09 101.06C832.09 133.26 817.28 155.71 788.16 168.48C774.35 174.62 760.06 177.17 750.86 178.7L661.41 22.9ZM854.53 358.37L763.15 199.59C774.57 197.74 785.72 194.47 796.34 189.87C834.17 173.54 854.08 142.91 854.08 101.56C854.08 60.21 834.17 29.57 796.34 13.23C778.73 5.65 759.81 1.48 740.64 1H623.94L727.37 180.19H632.13V358.38H654.03V201.09H737.17L824.77 358.38H854.53V358.37ZM1125.89 22.9V1H915.85V358.38H1125.9V334.49H936.75V22.9H1125.89ZM1585.35 22.9C1585.87 22.9 1619.58 22.9 1653.3 42.81C1697.29 68.35 1719.19 114.35 1719.19 179.19C1719.19 219.01 1711.01 251.73 1694.14 277.26L1527.64 22.9H1584.81M1681.02 293.67C1673.25 301.41 1664.49 308.11 1654.97 313.58C1621.77 332.99 1587.54 333.49 1587.03 333.49H1520.1V46.87L1681.02 293.67ZM1740.75 179.72C1740.75 129.17 1727.47 60.74 1662.63 23.49C1624.39 1 1586.09 1 1584.56 1H1495.22V358.38H1584.56C1586.09 358.38 1624.38 358.38 1662.68 335.91C1727.52 298.63 1740.8 230.23 1740.8 179.69M1312.98 0L1237.72 179.19H974.58V204.08H1227.83L1162.46 358.38H1186.96L1206.35 313.21L1215.52 290.88L1252.32 204.08H1331.96V179.19H1262.22L1312.99 58.37L1410.44 290.32L1420.14 312.85L1439.05 358.41H1464.05L1312.98 0Z" fill="#d1d5db"></path><path d="M1761.59 1C1778.59 1 1791 13.58 1791 30.5C1791 47.42 1778.59 59.99 1761.59 59.99C1744.59 59.99 1732.18 47.41 1732.18 30.5C1732.18 13.59 1744.59 1 1761.59 1ZM1761.59 5.26C1747.22 5.26 1736.94 16.39 1736.94 30.5C1736.94 44.69 1747.31 55.74 1761.59 55.74C1775.87 55.74 1786.23 44.69 1786.23 30.5C1786.24
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1Available on the AWS Marketplace</span></div></a><a class="flex flex-col gap-4 group/link" href="/platformsupport"><div class="w-[56px] h-[56px] flex items-center justify-center"><img alt="" loading="lazy" width="43" height="42" decoding="async" data-nimg="1" style="color:transparent" src="/_next/static/media/supportIcon.ef6370b8.svg"/></div><div class="prose prose-sm dark:prose-invert"><h3 class="text-sm mb-1">Need Help?</h3><span class="transition-all group-hover/link:text-foreground">Visit our Platform User Support</span></div></a></div></div><div class="mt-16 grid grid-cols-1 gap-x-12 gap-y-12 lg:mt-20 lg:grid-cols-[minmax(0,1fr)_minmax(0,1.05fr)] xl:grid-cols-[minmax(0,0.95fr)_minmax(0,1.15fr)_minmax(0,1.6fr)] xl:gap-x-14"><div class="space-y-10"><div><h3 class="text-base font-medium text-foreground"><a href="/advancing-research-offerings">Solutions</a></h3><ul class="mt-3 space-y-3"><li><a class="text-base text-muted-foreground transition-colors hover:text-foreground" href="/solutions/pcor">Ask the Right Questions</a></li><li><a class="text-base text-muted-foreground transition-colors hover:text-foreground" href="/solutions/listen">Listen and Co-create</a></li><li><a class="text-base text-muted-foreground transition-colors hover:text-foreground" href="/solutions/collect-data">Capture All Study Data</a></li></ul></div><div><h3 class="text-base font-medium text-foreground"><a href="/services">Consultative Services</a></h3><div class="mt-3 space-y-5"><div><h4 class="text-[0.72rem] font-semibold uppercase leading-[1.35] tracking-[0.08em] text-muted-foreground text-balance">Enablement Services</h4><ul class="mt-3 space-y-3"><li><a class="text-base text-muted-foreground transition-colors hover:text-foreground" href="/services/design">Define</a></li><li><a class="text-base text-muted-foreground transition-colors hover:text-foreground" href="/services/support">Support</a></li><li><a class="text-base text-muted-foreground transition-colors hover:text-foreground" href="/services/device-provisioning">Device Provisioning</a></li><li><a class="text-base text-muted-foreground transition-colors hover:text-foreground" href="/services/ecoa-license-management">Instrument Licensing</a></li><li><a class="text-base text-muted-foreground transition-colors hover:text-foreground" href="/services/training">Training</a></li><li><a class="text-base text-muted-foreground transition-colors hover:text-foreground" href="/services/translation">Translation</a></li><li><a class="text-base text-muted-foreground transition-colors hover:text-foreground" href="/services/study-configuration">Study Configuration</a></li></ul></div><div><h4 class="text-[0.72rem] font-semibold uppercase leading-[1.35] tracking-[0.08em] text-muted-foreground text-balance">PCOR Services</h4><ul class="mt-3 space-y-3"><li><a class="text-base text-muted-foreground transition-colors hover:text-foreground" href="/services/pcor">Endpoint Strategy</a></li><li><a class="text-base text-muted-foreground transition-colors hover:text-foreground" href="/services/pcor#instrument-development">Instrument Development</a></li></ul></div><div><h4 class="text-[0.72rem] font-semibold uppercase leading-[1.35] tracking-[0.08em] text-muted-foreground text-balance">Partnerships</h4><ul class="mt-3 space-y-3"><li><a class="text-base text-muted-foreground transition-colors hover:text-foreground" href="/services/partnerships">Integrated Solutions</a></li></ul></div></div></div><div><h3 class="text-base font-medium text-foreground"><a href="/one-decentralized-platform/powered-by-ai">Powered By AI</a></h3></div><div><h3 class="text-base font-medium text-foreground">About Us + Resources</h3><ul class="mt-3 space-y-3"><li><a class="text-base text-muted-foreground transition-colors hover:text-foreground" href="/resources">Resources</a></li><li><a class="text-base text-muted-foreground transition-colors hover:text-foreground" href="/management">THREAD Management Team</a></li><li><a class="text-base text-muted-foreground transition-colors hover:text-foreground" href="/pcor-team">PCOR Team</a></li><li><a class="text-base text-muted-foreground transition-colors hover:text-foreground" href="/careers">Careers</a></li><li><a class="text-base text-muted-foreground transition-colors hover:text-foreground" href="/press-releases">Press Releases</a></li><li><a class="text-base text-muted-foreground transition-colors hover:text-foreground" href="/contact">Contact Us</a></li><li><a class="text-base text-muted-foreground transition-colors hover:text-foreground" href="/social">Social and External Websites</a></li></ul></div></div><div class="space-y-8"><h3 class="text-base font-medium text-foreground"><a href="/fit-for-purpose-solutions">
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1<script id="__NEXT_DATA__" type="application/json">{"props":{"pageProps":{"press":{"_createdAt":"2026-09-29T17:45:10Z","_id":"3318f089-6227-4a74-9cb6-a92fb2ce9c81","body":[{"_key":"6f4782a5adee","_type":"block","children":[{"_key":"4bf44a8ceadb","_type":"span","marks":[],"text":"Since launching its Adaptive Trial solution, THREAD has helped design several new adaptive studies using the platform's new configurable workflows"}],"markDefs":[],"style":"h3"},{"_key":"d50894afcdbb","_type":"block","children":[{"_key":"edeee9511fc4","_type":"span","marks":["strong"],"text":"CARY, N.C., 30 SEP 2026"},{"_key":"ef5fd05e9521","_type":"span","marks":[],"text":" â THREAD, a leading no-code clinical research technology platform with scientific consulting for decentralized clinical trials (DCT) and electronic clinical outcome assessments (eCOA), today announced that biopharmaceutical sponsors and CROs have already designed several global adaptive clinical trials using the companies recently launched Adaptive Trials Solution. The milestone highlights growing industry demand for configurable technology and enablement services to simplify the operational complexity of modern clinical trial designs while speeding up study launch timelines."}],"markDefs":[],"style":"normal"},{"_key":"b54236fa1a8d","_type":"block","children":[{"_key":"73372931b227","_type":"span","marks":[],"text":"Building on the "},{"_key":"432d14e71edf","_type":"span","marks":["c8548d3df37f"],"text":"launch of its Adaptive Trials Solution"},{"_key":"d45b033e5838","_type":"span","marks":[],"text":" earlier this year, THREAD's configurable platform enables sponsors to operationalize basket, umbrella, multi-arm, and other adaptive study designs within a single protocol. Since the feature's release, sponsors have leveraged the platform to rapidly configure complex participant pathways, cohort management, protocol adaptations, and study governance without custom development on global Phase Ib â IV clinical trials and registries."}],"markDefs":[{"_key":"c8548d3df37f","_type":"link","href":"https://www.threadresearch.com/press-releases/thread-launches-new-adaptive-trials-solution"}],"style":"normal"},{"_key":"a20e2a7d4dc3","_type":"block","children":[{"_key":"f3a91fb041b6","_type":"span","marks":[],"text":"The adoption aligns with recent regulations that continue to encourage more efficient approaches to evidence generation. "},{"_key":"7efd41bf3294","_type":"span","marks":["b3e5b7472a02"],"text":"Recent FDA initiatives"},{"_key":"60ff98947147","_type":"span","marks":[],"text":" supporting the use of well-designed single pivotal trials, alongside expanded guidance for adaptive clinical trial designs, are creating new opportunities for sponsors to accelerate development while maintaining rigorous scientific standards. Adaptive trials allow sponsors to make pre-specified modifications based on interim data that help optimize patient enrollment, allocate resources more effectively, and potentially reach pivotal endpoints with greater eff
1iciency when appropriately planned."}],"markDefs":[{"_key":"b3e5b7472a02","_type":"link","href":"https://www.fda.gov/industry/fda-actions-accelerate-and-modernize-early-and-late-stage-clinical-development"}],"style":"normal"},{"_key":"69b579313145","_type":"block","children":[{"_key":"ec7f5975488d","_type":"span","marks":[],"text":"THREAD's Adaptive Trials Solution provides research teams with configurable workflows that support:"}],"markDefs":[],"style":"normal"},{"_key":"8f922559ea47","_type":"block","children":[{"_key":"1fe444f24aea","_type":"span","marks":[],"text":"Dynamic participant pathways across multiple cohorts and treatment arms"}],"level":1,"listItem":"bullet","markDefs":[],"style":"normal"},{"_key":"e8ad958b9dd3","_type":"block","children":[{"_key":"38bd00dab38e","_type":"span","marks":[],"text":"Rapid implementation of protocol adaptations"}],"level":1,"listItem":"bullet","markDefs":[],"style":"normal"},{"_key":"dfb7e5aab37f","_type":"block","children":[{"_key":"c1080b4ec63e","_type":"span","marks":[],"text":"Role-based governance for participant transitions"}],"level":1,"listItem":"bullet","markDefs":[],"style":"normal"},{"_key":"3d43174048a7","_type":"block","children":[{"_key":"da003c2fd0ab","_type":"span","marks":[],"text":"Automated visit and task management that maintains a seamless participant experience"}],"level":1,"listItem":"bullet","markDefs":[],"style":"normal"},{"_key":"37e299c657e1","_type":"block","children":[{"_key":"e7babcfceee1","_type":"span","marks":[],"text":"A single study configuration capable of supporting evolving trial designs"}],"level":1,"listItem":"bullet","markDefs":[],"style":"normal"},{"_key":"c04e5856105b","_type":"block","children":[{"_key":"378d64424e54","_type":"span","marks":[],"text":"\"We're seeing a meaningful shift in how sponsors think about pivotal trial design and the volume of adaptive study designs we are receiving,\" said John Reites, Co-founder and CEO of THREAD. \"We are grateful for the opportunity to support our clients with these new adaptive clinical trials to demonstrate how our platform and scientific consulting deliver the results they need in a partner.â"}],"markDefs":[],"style":"normal"},{"_key":"68790af61850","_type":"block","children":[{"_key":"c2f310c1245b","_type":"span","marks":[],"text":"To learn more about THREAD's Adaptive Trials Solution or schedule a demonstration, visit "},{"_key":"7b319fd8ab85","_type":"span","marks":["eec24a91d84d"],"text":"https://www.threadresearch.com/adaptive-trial"}],"markDefs":[{"_key":"eec24a91d84d","_type":"link","href":"https://www.threadresearch.com/adaptive-trial"}],"style":"normal"},{"_key":"7ea1e34611c9","_type":"block","children":[{"_key":"db3687dfef52","_type":"span","marks":[],"text":""}],"markDefs":[],"style":"normal"},{"_key":"e3eff157bb5b","_type":"block","children":[{"_key":"c7359d0d56de","_type":"span","marks":[],"text":"##"}],"markDefs":[],"style":"normal"},{"_key":"6e7d81c19f6f","_type":"block","children":[{"_key":"40925d382056","_type":"span","marks":[],"text":""}],"markDefs":[],"style":"normal"},{"_key":"b51db1cd130b","_type":"block","children":[{"_key":"137005a0ad4e","_type":"span","marks":["strong"],"text":"About THREAD"}],"markDefs":[],"style":"normal"},{"_key":"1a8caaf472f9","_type":"block","children":[{"_key":"ab9b7156ba29","_type":"span","marks":[],"text":"THREADâs® purpose is to leverage its clinical research platform to enable studies for everyone, everywhere. Through its uniquely combined research technology and scientific consulting services, THREAD helps life science organizations to design, operate, and scale next-generation research studies and electronic clinical outcome assessments (eCOA) programs for participants, sites, and study teams. 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